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1 Dirty Genes - Ben Lynch
Auteur : Ben Lynch
Genre : Diet & Nutrition
Instant National Bestseller

After suffering for years with unexplainable health issues, Dr. Ben Lynch discovered the root cause—“dirty” genes. Genes can be “born dirty” or merely “act dirty” in response to your environment, diet, or lifestyle—causing lifelong, life-threatening, and chronic health problems, including cardiovascular disease, autoimmune disorders, anxiety, depression, digestive issues, obesity, cancer, and diabetes.

Based on his own experience and successfully helping thousands of clients, Dr. Lynch shows you how to identify and optimize both types of dirty genes by cleaning them up with targeted and personalized plans, including healthy eating, good sleep, stress relief, environmental detox, and other holistic and natural means.

Many of us believe our genes doom us to the disorders that run in our families. But Dr. Lynch re

2 IBM Spectrum Scale Best Practices for Genomics Medicine Workloads - Joanna Wong, Kevin Gildea, Kumaran Rajaram, Luis Bolinches, Monica Lemay, Piyush Chaudhary, Sandeep R. Patil & Ulf Troppens
Auteur : Joanna Wong, Kevin Gildea, Kumaran Rajaram, Luis Bolinches, Monica Lemay, Piyush Chaudhary, Sandeep R. Patil & Ulf Troppens
Genre : Computers
Advancing the science of medicine by targeting a disease more precisely with treatment specific to each patient relies on access to that patient's genomics information and the ability to process massive amounts of genomics data quickly. Although genomics data is becoming a critical source for precision medicine, it is expected to create an expanding data ecosystem.

Therefore, hospitals, genome centers, medical research centers, and other clinical institutes need to explore new methods of storing, accessing, securing, managing, sharing, and analyzing significant amounts of data. Healthcare and life sciences organizations that are running data-intensive genomics workloads on an IT infrastructure that lacks scalability, flexibility, performance, management, and cognitive capabilities also need to modernize and transform their infrastructure to support current and future requireme

3 A Troublesome Inheritance - Nicholas Wade
Auteur : Nicholas Wade
Genre : Life Sciences
Drawing on startling new evidence from the mapping of the genome, an explosive new account of the genetic basis of race and its role in the human story
Fewer ideas have been more toxic or harmful than the idea of the biological reality of race, and with it the idea that humans of different races are biologically different from one another. For this understandable reason, the idea has been banished from polite academic conversation. Arguing that race is more than just a social construct can get a scholar run out of town, or at least off campus, on a rail. Human evolution, the consensus view insists, ended in prehistory.

Inconveniently, as Nicholas Wade argues in A Troublesome Inheritance, the consensus view cannot be right. And in fact, we know that populations have changed in t

4 Spiritual Genomics - Jr. M.D. Fred L Grover & Margaret A. Harrell
Auteur : Jr. M.D. Fred L Grover & Margaret A. Harrell
Genre : Spirituality
Spiritual genomics is an exploration into the role of mindful based activities that can enhance your genome (DNA) to a healthier state. Unique and diverse approaches to mindfulness are discussed by integrative medicine physician Fred Grover Jr. M.D. Join him in adventures to Peru and the ocean blue, as he also discusses benefits of meditation, dance, yoga, sound therapy, sacred geometry, sacred sites, nature, water, and plant medicine. Interviews with world renowned artists, dancers and sound healers are woven into the book. Let the journey begin!
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6 Generosity - Richard Powers
Auteur : Richard Powers
Genre : Literary

When Chicagoan Russell Stone finds himself teaching a Creative Nonfiction class, he encounters a young Algerian woman with a disturbingly luminous presence. Thassadit Amzwar's blissful exuberance both entrances and puzzles the melancholic Russell. How can this refugee from perpetual terror be so happy? Won't someone so open and alive come to serious harm? Wondering how to protect her, Russell researches her war-torn country and skims through popular happiness manuals. Might her condition be hyperthymia? Hypomania? Russell's amateur inquiries lead him to college counselor Candace Weld, who also falls under Thassa's spell. Dubbed Miss Generosity by her classmates, Thassa's joyful personality comes to the atte

7 IBM Reference Architecture for Genomics, Power Systems Edition - Dino Quintero, Luis Bolinches, Marcelo Correia Lima, Katarzyna Pasierb & William dos Santos
Auteur : Dino Quintero, Luis Bolinches, Marcelo Correia Lima, Katarzyna Pasierb & William dos Santos
Genre : Computers
This IBM® Redbooks® publication introduces the IBM Reference Architecture for Genomics, IBM Power Systems™ edition on IBM POWER8®. It addresses topics such as why you would implement Life Sciences workloads on IBM POWER8, and shows how to use such solution to run Life Sciences workloads using IBM Platform™ Computing software to help set up the workloads. It also provides technical content to introduce the IBM POWER8 clustered solution for Life Sciences workloads.

This book customizes and tests Life Sciences workloads with a combination of an IBM Platform Computing software solution stack, Open Stack, and third party applications. All of these applications use IBM POWER8, and IBM Spectrum Scale™ for a high performance file system.

This book helps strengthen IBM Life Sciences solutions on IBM POWER8 with a well-defined and documented deployment model within a

8 Genomics - Stephen D. Krau
Auteur : Stephen D. Krau
Genre : Nursing
This issue of Nursing Clinics of North America is Guest Edited by  Stephen D. Krau, PhD, RN, CNE, from Vanderbilt University and will focus on genomics. Article topics will include Genetic and Genomic Testing, Integrating Genomics into Research, Genomic Assessments and Interventions in Psychiatric Nursing Practice, Genomics in Critical Care, Cardiomyopathy and Genetics, Genetics and Chronic Diseases, Genomics and Patients with Rare Chronic Diseases, Epigenetics and the implications for disease processes, Impact of Genetics on Oncology Nursing, and Pharmacogenetics.

9 Bioinformatics and Functional Genomics - Jonathan Pevsner
Auteur : Jonathan Pevsner
Genre : Life Sciences
The bestselling introduction to bioinformatics and genomics – now in its third edition

Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.

This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:
Extensive revisions and a slight reorder of chapters for a more effective organization A brand new chapter on next-generation sequencing An expanded companion website, also updated as and when new information becomes available Greater emphasis on a computational approach, with clear guidance of how software tools work an

10 Genomics: A Very Short Introduction - John M. Archibald
Auteur : John M. Archibald
Genre : Biology
In the years since the Human Genome Project, genomics has grown into a big and rapidly developing field driven by bioinformatics technology. The implications for our health and privacy, and our understanding of ecological systems and evolution are profound. This book provides an account of this exciting new science, its impact and its potential.

11 Genetics and Genomics In Nursing and Health Care - Theresa A. Beery & M. Linda Workman
Auteur : Theresa A. Beery & M. Linda Workman
Genre : Medical
Awarded a 2012 AJN Book of the Year Award! Build the foundation you need to understand the science of genetics and its growing role in the diagnosis and treatment of diseases and disorders. Two experts in the field present the biological, psychological, and social implications of genetic influences in health care in an easy-to-read and -understand style. Inside, you’ll find the thorough coverage and clinical examples you need to understand the basis of genetic inheritance, the influence of somatic and germline mutations, the multifactorial relationship of gene-environment interactions, and the foundation of ethical behavior in providing comprehensive genetic nursing care. It’s perfect for both stand-alone courses or integrated into courses across the curriculum.

12 As the Future Catches You - Juan Enriquez
Auteur : Juan Enriquez
Genre : Life Sciences
You will never look at the world in the same way after reading As the Future Catches You. Juan Enriquez puts you face to face with a series of unprecedented political, ethical, economic, and financial issues, dramatically demonstrating the cascading impact of the genetic, digital, and knowledge revolutions on your life.

Genetics will be the dominant language of this century. Those who can “speak it” will acquire direct and deliberate control over all forms of life. But most countries and individuals remain illiterate in what is rapidly becoming the greatest single driver of the global economy.

Wealth will be more concentrated and those with knowledge to sell–both countries and individuals–will be the winners.

Consider what will happen when:
• Your genetic code can be digitally imprinted on an ID card and your insurance company and

13 The Agile Gene - Matt Ridley
Auteur : Matt Ridley
Genre : Science & Nature
Armed with extraordinary new discoveries about our genes, acclaimed science writer Matt Ridley turns his attention to the nature-versus-nurture debate in a thoughtful book about the roots of human behavior.

Ridley recounts the hundred years' war between the partisans of nature and nurture to explain how this paradoxical creature, the human being, can be simultaneously free-willed and motivated by instinct and culture. With the decoding of the human genome, we now know that genes not only predetermine the broad structure of the brain, they also absorb formative experiences, react to social cues, and even run memory. They are consequences as well as causes of the will.

14 One in a Billion - Mark Johnson & Kathleen Gallagher
Auteur : Mark Johnson & Kathleen Gallagher
Genre : Biographies & Memoirs
“A riveting scientific detective story” (The Washington Post) by two Pulitzer Prize–winning journalists who chronicle a young Wisconsin boy with a never-before-seen disease and the doctors who save his life by taking a new step into the future of medicine.

In this landmark medical narrative, Pulitzer Prize-winning journalists Mark Johnson and Kathleen Gallagher share the story of Nic Volker, the first patient to be saved by a bold breakthrough in medicine—a complete gene sequencing, aimed at finding the cause of an otherwise undiagnosable illness. At just two years old, Nic experienced a brief flicker of pain that signaled the awakening of a new and deadly disease, one that would hurl him and his family into a harrowing journey in search for a lifesaving cure. After his symptoms stump every practitioner, it becomes clear that Nic’s is a one in a billion case,

15 Here Is a Human Being - Misha Angrist
Auteur : Misha Angrist
Genre : Science & Nature
Here is a Human Being delivers the first in-depth look at the Personal Genome Project—the effort to construct complete genomic maps of a specific human beings—written by one of the study’s ten human participants. Misha Angrist recounts the project’s fascinating nuances, including the larger-than-life personalities of the research subjects, the entrepreneurial scientists at the helm, the bewildered and overwhelmed physicians and regulators who negotiated for it, the fascinating technology it employed, and the political, social, ethical and familial issues it continues to raise. In the vein of James Shreeve’s The Genome War, Craig J. Ventner’s My Life Decoded, and Francis J. Collins’ The Language of Life, Angrist’s informed exploration of this cutting-edge science is a gripping look at the present and future of genomics.

16 The Creative Destruction of Medicine - Eric Topol
Auteur : Eric Topol
Genre : Engineering
How genomics, big data, and digital technology are revolutionizing every aspect of medicine, from physical exams to drug prescriptions to organ transplants

Mobile technology has transformed our lives, and personal genomics is revolutionizing biology. But despite the availability of technologies that can provide wireless, personalized health care at lower cost, the medical community has resisted change. In The Creative Destruction of Medicine, Eric Topol-one of the nation's top physicians-calls for consumer activism to demand innovation and the democratization of medical care. The Creative Destruction of Medicine is the definitive account of the coming disruption of medicine, written by the field's leading voice.

17 DNA - James D. Watson, Andrew Berry & Kevin Davies
Auteur : James D. Watson, Andrew Berry & Kevin Davies
Genre : Life Sciences
The definitive insider's history of the genetic revolution--significantly updated to reflect the discoveries of the last decade.

James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, agricultural chemistry, as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact--practical, social, and ethical--on our society and our world.

18 Genetics 101 - Beth Skwarecki
Auteur : Beth Skwarecki
Genre : Life Sciences
A clear and straightforward explanation of genetics in this new edition of the popular 101 series.

Our genetic makeup determines so much about who we are, and what we pass on to our children—from eye color, to height, to health, and even our longevity. Genetics 101 breaks down the science of how genes are inherited and passed from parents to offspring, what DNA is and how it works, how your DNA affects your health, and how you can use your personal genomics to find out more about who you are and where you come from.

Whether you’re looking for a better scientific understanding of genetics, or looking into your own DNA, Genetics 101 is your go-to source to discover more about both yourself and your ancestry.

19 Genomics and Public Health: Potential Benefits Depend on Linking Genetic and Environmental Data in Designing Research, Developing Applications, And Forging Public Policies. - Issues in Science and Technology
Auteur : Issues in Science and Technology
Genre : Engineering
Breakthroughs in biology are changing our world. Just as chemistry and physics had broad ramifications in the preceding centuries, the New Biology unleashed by the Human Genome Project and associated developments will send ripples through many aspects of 21st-century life and will be influential in improving the health of the public. The public health sciences will be essential for interpreting the health significance of genetic variation and the gene/environment interactions at the core of most diseases and biological phenomena. The combination of genomics and public health sciences will be critical to achieve the vision of predictive, personalized, preventive health care and community health services (Table 1). Public and media interest was intense when President Bill Clinton and Prime Minister Tony Blair jointly announced accelerated progress by the public- and private-sector sequenci

20 Cancer Genomics for the Clinician - Ramaswamy Govindan MD & Ashiq Masood MD
Auteur : Ramaswamy Govindan MD & Ashiq Masood MD
Genre : Medical
Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointes

21 The Genome Factor - Dalton Conley & Jason Fletcher
Auteur : Dalton Conley & Jason Fletcher
Genre : Sociology
How genomics is revolutionizing the social sciences

For a century, social scientists have avoided genetics like the plague. But the nature-nurture wars are over. In the past decade, a small but intrepid group of economists, political scientists, and sociologists have harnessed the genomics revolution to paint a more complete picture of human social life than ever before. The Genome Factor describes the latest astonishing discoveries being made at the scientific frontier where genomics and the social sciences intersect.

The Genome Factor reveals that there are real genetic differences by racial ancestry—but ones that don't conform to what we call black, white, or Latino. Genes explain a significant share of who gets ahead in society and who does not, but instead of giving rise to a genotocracy, genes often act as engines of mobility that counte

22 Genomics & Computation - GeneDrop Inc.
Auteur : GeneDrop Inc.
Genre : Life Sciences
Designing In Silico Pipelines to Stratify Individual Patient Response With Adverse Event Markers

23 Genomics in the Cloud - Geraldine A. Van der Auwera & Brian D. O'Connor
Auteur : Geraldine A. Van der Auwera & Brian D. O'Connor
Genre : Computers & Internet
Data in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytes—or over 50 million gigabytes—of genomic data, and they’re turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud?

With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian O’Connor of the UC Santa Cruz Genomics Institute, guide you through the process. You’ll learn by working with real data and genomics algorithms from the field.

This book covers:
Essential genomics and comput

24 Genetics/Genomics Nursing - American Nurses Association & International Society of Nurses in Genetics
Auteur : American Nurses Association & International Society of Nurses in Genetics
Genre : Medical
Completely updated by genetics/genomics nurses for genetics/genomics nurses. The first best resource for the RN or APRN genetics/genomics nurse at any level and in any setting. Essential for all involved in this nursing practice specialty now and throughout this decade.
Genetics/genomics nursing practice and care focuses on the actual and potential impact of genetic and genomic influences on health. These nurses advise and educate clients and families on such influences that might impact their health, identify and manage physiologic responses. The goals of their nursing interventions: to optimize health, reduce health risks, treat disease, and promote wellness. Their research and evidence-based practice also includes interprofessional collegiality and collaboration with other genetics/genomics professionals and other healthcare professionals to provide quality patient care.
A w

25 Creating a New Racial Order - Jennifer L. Hochschild, Vesla M. Weaver & Traci R. Burch
Auteur : Jennifer L. Hochschild, Vesla M. Weaver & Traci R. Burch
Genre : Political Science
The American racial order--the beliefs, institutions, and practices that organize relationships among the nation's races and ethnicities--is undergoing its greatest transformation since the 1960s. Creating a New Racial Order takes a groundbreaking look at the reasons behind this dramatic change, and considers how different groups of Americans are being affected. Through revealing narrative and striking research, the authors show that the personal and political choices of Americans will be critical to how, and how much, racial hierarchy is redefined in decades to come.

The authors outline the components that make up a racial order and examine the specific mechanisms influencing group dynamics in the United States: immigration, multiracialism, genomic science, and generational change. Cumulatively, these mechanisms increase heterogeneity within each racial or ethnic grou

26 Oil Palm Breeding - Aik Chin Soh, Sean Mayes & Jeremy A. Roberts
Auteur : Aik Chin Soh, Sean Mayes & Jeremy A. Roberts
Genre : Life Sciences
The oil palm is a remarkable crop, producing around 40% of the world’s vegetable oil from around 6% of the land devoted to oil crops. Conventional breeding has clearly been the major focus of genetic improvement in this crop. A mix of improved agronomy and management, coupled with breeding selection have quadrupled the oil yield of the crop since breeding began in earnest in the 1920s. However, as for all perennial crops with long breeding cycles, oil palm faces immense challenges in the coming years with increased pressure from population growth, climate change and the need to develop environmentally sustainable oil palm plantations.

In Oil Palm: Breeding, Genetics and Genomics, world leading organizations and individuals who have been at the forefront of developments in this crop, provide their insights and experiences of oil palm research, while examining the diff

27 Troublesome Science - Rob DeSalle & Ian Tattersall
Auteur : Rob DeSalle & Ian Tattersall
Genre : Life Sciences
It is well established that all humans today, wherever they live, belong to one single species. Yet even many people who claim to abhor racism take for granted that human “races” have a biological reality. In Troublesome Science, Rob DeSalle and Ian Tattersall provide a lucid and forceful critique of how scientific tools have been misused to uphold misguided racial categorizations.

DeSalle and Tattersall argue that taxonomy, the scientific classification of organisms, provides an antidote to the myth of race’s biological basis. They explain how taxonomists do their science—how to identify a species and to understand the relationships among different species and the variants within them. DeSalle and Tattersall also detail the use of genetic data to trace human origins and look at how scientists have attempted to recognize discrete populations within Homo sapie

28 Editing Mankind - Kevin Davies
Auteur : Kevin Davies
Genre : Life Sciences
One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. 

If our genes are, to a great extent, destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability. But this power to “play God” also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Davies powerfully reveals in his new book, this is all about to change.

Engrossing and page-turning, Editing Mankind takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to

29 Human Genome Informatics - Christophe Lambert, Darrol Baker & George P. Patrinos
Auteur : Christophe Lambert, Darrol Baker & George P. Patrinos
Genre : Medical
Human Genome Informatics: Translating Genes into Health examines the most commonly used electronic tools for translating genomic information into clinically meaningful formats. By analyzing and comparing interpretation methods of whole genome data, the book discusses the possibilities of their application in genomic and translational medicine. Topics such as electronic decision-making tools, translation algorithms, interpretation and translation of whole genome data for rare diseases are thoroughly explored. In addition, discussions of current human genome databases and the possibilities of big data in genomic medicine are presented.

With an updated approach on recent techniques and current human genomic databases, the book is a valuable source for students and researchers in genome and medical informatics. It is also ideal for workers in the bioinformatics industry who

30 Immortality, Inc. - Chip Walter
Auteur : Chip Walter
Genre : Science & Nature
This gripping narrative explores today's scientific pursuit of immortality, with exclusive visits inside Silicon Valley labs and interviews with the visionaries who believe we will soon crack into the aging process and cure death.

We live in an age when billionaires are betting their fortunes on laboratory advances to prove aging unnecessary and death a disease that can be cured. Researchers are delving into the mysteries of stem cells and the human genome, discovering what it means to grow old and how to keep those processes from happening. This isn't science fiction; it's real, it's serious, and it's on track to revolutionize our definitions of life and mortality.

In Immortality, Inc., veteran science journalist Chip Walter gains exclusive access to the champions of this radical cause, delivering a book that brings together for the fir

31 FOCUS: Juan Enriquez - Bob Magnant
Auteur : Bob Magnant
Genre : Computers
This first FOCUS book of the ‘Fingertips’ series will help you to connect with the technology of smart devices. Emphasis on data communications and digital technology are rapidly changing our lives and our activities while our communications skills are being overloaded by new information everyday. Juan Enriquez open our eyes to the power of information in the near future that is both unique and frightening. Biogenomics is not only defining how we will evolve but what we can be as well. Future healthcare systems will define our new quality of life and how we shall continue to prosper as this planet’s dominant species.

32 The National Academies Keck Futures Initiative The Genomic Revolution -- Implications for Treatment and Control of Infectious Disease - The National Academies Keck Futures Initiative Genomics Steering Committee
Auteur : The National Academies Keck Futures Initiative Genomics Steering Committee
Genre : Life Sciences
The 2005 conference, "The Genomic Revolution: Implications for Treatment and Control of Infectious Disease," attracted scientists, engineers, and medical researchers to work on new interdisciplinary responses using genomics to treat and control infectious diseases. Eleven conference working groups gave the participants eight hours to develop new research approaches to problems in infectious disease using genomics. Among the challenges were designing a new device to detect viral and bacterial pathogens; how best to use $100 million to prevent a future pandemic flu outbreak; how to improve rapid response to an outbreak of disease and reduce the cost of diagnostic tests; and how to sequence an individual's genome for under $1,000. Representatives from public and private funding organizations, government, industry, and the science media also participated in the working groups. This book prov

33 Review of the Department of Energy's Genomics: GTL Program - Committee on Review of the Department of Energy's Genomics: GTL Program
Auteur : Committee on Review of the Department of Energy's Genomics: GTL Program
Genre : Life Sciences
The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL’s research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE’s goals. However, the DOE’s current plan for building four independent f

34 Seeking Security - Committee on Genomics Databases for Bioterrorism Threat Agents
Auteur : Committee on Genomics Databases for Bioterrorism Threat Agents
Genre : Life Sciences
Within the last 30 years, the genomes of thousands of organisms, from viruses, to bacteria, to humans, have been sequenced or partially sequenced and deposited in databases freely accessible to scientists around the world. This information is accelerating scientists' ability to fight disease and make other medical advances, but policymakers must consider the possibility that the information could also be used for destructive purposes in acts of bioterrorism or war. Based in part on views from working biological scientists, the report concludes that current policies that allow scientists and the public unrestricted access to genome data on microbial pathogens should not be changed. Because access improves our ability to fight both bioterrorism and naturally occurring infectious diseases, security against bioterrorism is better served by policies that facilitate, not limit, the free flow o

35 From Human Genome Research to Personalized Health Care: The Potential Is Widely Recognized, But Much More Knowledge Is Needed to Make the Science Clinically Useful (Genomics IN HEALTH Care) (Viewpoint Essay) - Issues in Science and Technology
Auteur : Issues in Science and Technology
Genre : Engineering
"Big Science" in the life sciences was launched in 1986 with a bold plan to develop the technologies to determine the sequence of the 3 billion nucleotide base pairs (letters of DNA code) in the human genome. The Human Genome Project declared success by 2001 and has stimulated a wealth of related research. Analyses of the genomes of many organisms have yielded powerful evidence of sequences conserved during evolution. Analyses of microorganisms set the stage for pathogen/host interaction studies. Essentially all fields of life sciences research have been transformed by knowledge of protein-coding genes, recognition of genomic variation across individuals, findings of new mechanisms of regulation of gene expression, and patterns of proteins and metabolites in generating the features of living organisms. From the beginning, there have been high expectations that such knowledge would enhanc

36 Der Experimentator Molekularbiologie / Genomics - Cornel Mülhardt
Auteur : Cornel Mülhardt
Genre : Biology

wir präsentieren Ihnen hier das Grundlagenwissen sowie Tipps und Tricks für den Umgang mit Nucleinsäuren. Sie werden sofort merken, dass der Autor Lust und Frust der täglichen Laborroutine genau kennt.

Aus dem Inhalt:
Präparieren, Fällen, Konzentrieren und Reinigen von NucleinsäurenDas molekularbiologische Handwerkszeug (Restriktionsenzyme, Gele, Blotten)PCR (Polymerase-Kettenreaktion)RNA-Isolierung, -TranskriptionKlonierung von DNA-FragmentenDNA-Nachweis und -Analyse (Markierung von Sonden, Hybridisierung, Screening, Sequenzierung)Modifikation und Funktionsanalyse von DNA-Sequenzen (Mutagenese, In-vitro-Translation, transgene Mäuse, Transgenexpression, Gentherapie, Genomik)Lieferantenverzeichnis
Protokoll-Sammlungen gibt es viele, aber wer erklärt einem, was sich hinter den Methoden verbirgt? Dieses Buch richtet sich an all

37 From Plant Genomics to Plant Biotechnology (Enhanced Edition) - Palmiro Poltronieri, Natalija Burbulis & Corrado Fogher
Auteur : Palmiro Poltronieri, Natalija Burbulis & Corrado Fogher
Genre : Life Sciences
With the appearance of methods for the sequencing of genomes and less expensive next generation sequencing methods, we face rapid advancements of the -omics technologies and plant biology studies: reverse and forward genetics, functional genomics, transcriptomics, proteomics, metabolomics, the movement at distance of effectors and structural biology. From plant genomics to plant biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, understanding the epigenetic control and epigenetic memory, the roles of non-coding RNAs, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics and plants modified to specific aims. In the forthcoming years these advancements will support the production of plant varieties better suited to resist biotic and abiotic str

38 Genetics and Genomics of Setaria - Andrew Doust & Xianmin Diao
Auteur : Andrew Doust & Xianmin Diao
Genre : Life Sciences
Setaria viridis and S.italica make up a model grass system to investigate C4 photosynthesis, cell wall biosynthesis, responses to drought, herbicide, and other environmental stressors, genome dynamics, developmental genetics and morphology, and interactions with microorganisms. Setaria viridis (green foxtail) is one of the world’s most widespread weeds, and its small size, native variation, rapidly burgeoning genetic and genomic resources, and transformability are making it the system of choice for both basic research and its translation into crop improvement. Its domesticated variant, S. italica (foxtail millet), is a drought-hardy cereal grown in China, India and Africa, and new breeding techniques show great potential for improving yields and nutrition for drought-prone regions. This book brings together for the first time evolutionary, g

39 Applied Genomics of Foodborne Pathogens - Xiangyu Deng, Henk C. den Bakker & Rene S. Hendriksen
Auteur : Xiangyu Deng, Henk C. den Bakker & Rene S. Hendriksen
Genre : MZGenre.ProfessionalTechnical.Engineering.eBooks.ChemicalPetroleumEngineering
This book provides a timely and thorough snapshot into the emerging and fast evolving area of applied genomics of foodborne pathogens. Driven by the drastic advance of whole genome shot gun sequencing (WGS) technologies, genomics applications are becoming increasingly valuable and even essential in studying, surveying and controlling foodborne microbial pathogens. The vast opportunities brought by this trend are often at odds with the lack of bioinformatics know-how among food safety and public health professionals, since such expertise is not part of a typical food microbiology curriculum and skill set. Further complicating the challenge is the large and ever evolving body of bioinformatics tools that can obfuscate newcomers to this area. Although reviews, tutorials and books are not in short supply in the fields of bioinformatics and genomics, until now there has not been a comprehensi

40 Conservation Genetics in the Age of Genomics - George Amato, Rob DeSalle, Oliver Ryder & Howard Rosenbaum
Auteur : George Amato, Rob DeSalle, Oliver Ryder & Howard Rosenbaum
Genre : Life Sciences
Genome sequencing enables scientists to study genes over time and to test the genetic variability of any form of life, from bacteria to mammals. Thanks to advances in molecular genetics, scientists can now determine an animal's degree of inbreeding or compare genetic variation of a captive species to wild or natural populations. Mapping an organism's genetic makeup recasts such terms as biodiversity and species and enables the conservation of rare or threatened species, populations, and genes.

By introducing a new paradigm for studying and preserving life at a variety of levels, genomics offers solutions to previously intractable problems in understanding the biology of complex organisms and creates new tools for preserving the patterns and processes of life on this planet. Featuring a number of high-profile researchers, this volume introduces the use of molecular genetics in

41 Root Genomics - Antonio Costa de Oliveira & Rajeev Varshney
Auteur : Antonio Costa de Oliveira & Rajeev Varshney
Genre : Life Sciences
With the predicted increase of the human population and the subsequent need for larger food supplies, root health in crop plants could play a major role in providing sustainable highly productive crops that can cope with global climate changes. While the essentiality of roots and their relation to plant performance is broadly recognized, less is known about the role of roots in plant growth and development. “Root Genomics” examines how various new genomic technologies are rapidly being applied to the study of roots, including high-throughput sequencing and genotyping, TILLING, transcription factor analysis, comparative genomics, gene discovery and transcriptional profiling, post-transcriptional events regulating microRNAs, proteome profiling and the use of molecular markers such as SSRs, DArTs, and SNPs for QTL analyses and the identification of superior genes/alleles. The book also

42 Genes and Genomics - Dilip K. Arora & Randy Berka
Auteur : Dilip K. Arora & Randy Berka
Genre : Medical
This latest volume addresses the contemporary issues related to recombination in filamentous fungi, EST data mining, fungal intervening sequences, gene silencing, DNA damage response in filamentous fungi, cfp genes of Neurospora, developmental gene sequences, site-specific recombination, heterologous gene expression, hybridization and microarray technology to enumerate biomass. This volume also analyse the current knowledge in the area of hydrophobins and genetic regulation of carotenoid biosynthesis. Over fifty world renowned scientist from both industry and academics provided in-depth information in the field of fungal genes and genomics.

43 Genomics, Proteomics, and the Nervous System - James D Clelland
Auteur : James D Clelland
Genre : Neuroscience
The potential for malfunction of this large number of complex biological systems is great, leading to the many behavioral and cognitive deficits observed in human psychiatric and neurological disorders. Genomics, Proteomics, and the Nervous System discusses research designed to increase our understanding of the nervous system and its structures and activities. This volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.

44 The Dictionary of Genomics, Transcriptomics and Proteomics, 4 Volume Set - Guenter Kahl
Auteur : Guenter Kahl
Genre : Life Sciences
Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked.

This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary.
The ultimate reference for all terms in the -omics fields.

45 Genetics and Genomics of the Triticeae - Catherine Feuillet & Gary J. Muehlbauer
Auteur : Catherine Feuillet & Gary J. Muehlbauer
Genre : Life Sciences
Genetics and Genomics of Triticeae

Edited by Catherine Feuillet and Gary Muehlbauer

Domestication of cereals in the Fertile Crescent 10,000 years ago ushered in the beginning of agriculture, and signified a remarkable breakthrough in the advancement of civilization. Today, the crops of the Triticeae tribe, wheat, barley, and rye, constitute over 50% of total crop production worldwide ( and cereal seeds are one of the most important renewable resources for food, feed, and industrial raw materials. The economic importance of the Triticeae has triggered intense cytogenetic and genetic studies over the past few decades, and has resulted in a breadth of information and tools for developing wheat, barley, and rye varieties. Hampered by the size and complexity of their genomes, however, research regarding the genomics of the Triticeae has lagged behind

46 Reproductive Genomics in Domestic Animals - Zhihua Jiang & Troy L. Ott
Auteur : Zhihua Jiang & Troy L. Ott
Genre : Life Sciences
Reproductive Genomics in Domestic Animals is a thorough examination of genomics in the livestock industry, encompassing genome sciences, genome biotechnology, and reproduction. Recent developments in molecular genetics and genomics have enabled scientists to identify and characterize genes contributing to the complexity of reproduction in domestic animals, allowing scientists to improve reproductive traits. Providing the livestock industry with essential tools for enhancing reproductive efficiency, Reproductive Genomics in Domestic Animals surveys the current status of reproductive genomes and looks to the future direction of research.

47 Comparative Genomics - Francesca D. Ciccarelli & Istvan Miklos
Auteur : Francesca D. Ciccarelli & Istvan Miklos
Genre : Life Sciences
This book constitutes the proceedings of the 7th RECOMB International Satellite Workshop on Comparative Genomics, RECOMB-CG 2009, Budapest, Hungary, in September 2009.

This workshop is devoted to bringing together scientists working on all aspects of comparative genomics, from computer scientists, mathematicians and statisticians working on novel computational approaches for genome analysis and comparison, to biologists applying these computational tools to study the structure and the evolution of prokaryotic and eukaryotic genomes.

The 19 papers presented were carefully reviewed and selected from 31 submissions. The papers illustrate the crucial role of comparative genomics in understanding genome function and address a broad variety of aspects, ranging from the inference of evolution in genetic regulatory networks to the divergent fates of gene and genome duplicat

48 Big Data Analytics in Genomics - Ka-Chun Wong
Auteur : Ka-Chun Wong
Genre : Computers
This contributed volume explores the emerging intersection between big data analytics and genomics. Recent sequencing technologies have enabled high-throughput sequencing data generation for genomics resulting in several international projects which have led to massive genomic data accumulation at an unprecedented pace.  To reveal novel genomic insights from this data within a reasonable time frame, traditional data analysis methods may not be sufficient or scalable, forcing the need for big data analytics to be developed for genomics. The computational methods addressed in the book are intended to tackle crucial biological questions using big data, and are appropriate for either newcomers or veterans in the field.This volume offers thirteen peer-reviewed contributions, written by international leading experts from different regions, representing Argentina, Brazil, China, France, Ge

49 Stress Signaling in Plants: Genomics and Proteomics Perspective, Volume 1 - Maryam Sarwat, Altaf Ahmad & MZ Abdin
Auteur : Maryam Sarwat, Altaf Ahmad & MZ Abdin
Genre : Life Sciences
The most important prerequisites imperative for survival of human kind food, fodder and fuel depends upon the performance of plants.  Due to worldwide temperature inversions, the weather conditions have become completely unpredictable and hostile.  Thus, there is a growing need of such plants which are better adapted to these adverse climatic conditions.  A good understanding of the signaling mechanism within the plant system during these climatic conditions will certainly going to help in raising plants which are better suited for these adverse conditions.

Stress Signaling in Plants: Genomics and Proteomics Perspective Volume 1 brings together both a Genomics and Proteomics approach to further our understanding in this direction. The volume expands on the current understanding from Bioinformatical approaches to develop the models, as we

50 Cardiovascular Genomics - Mohan K. Raizada, Julian F. R. Paton, Michael J. Katovich & Sergey Kasparov
Auteur : Mohan K. Raizada, Julian F. R. Paton, Michael J. Katovich & Sergey Kasparov
Genre : Medical
After more than 50 years of limited success in controlling blood pressure with traditional antihypertensive drugs, the time is ripe to explore alternate strategies for managing cardiovascular diseases. In Cardiovascular Genomics, recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. They involve genetic linkage analysis and substitution mapping using congenic strains, microarray techniques, and strategies for
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